InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC2A2

Summary

InnateDB Gene

IDBG-64695.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC2A2

Gene Name

solute carrier family 2 (facilitated glucose transporter), member 2

Synonyms

GLUT2

Species

Homo sapiens

Ensembl Gene

ENSG00000163581

Encoded Proteins

IDBP-64697

solute carrier family 2 (facilitated glucose transporter), member 2

IDBP-473561

solute carrier family 2 (facilitated glucose transporter), member 2

IDBP-474606

solute carrier family 2 (facilitated glucose transporter), member 2

IDBP-481829

solute carrier family 2 (facilitated glucose transporter), member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. [provided by RefSeq, Jul 2008]
This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:170996348-171026750

Strand

Reverse strand

Band

q26.2

Transcripts

ENST00000314251	ENSP00000323568
ENST00000497642	ENSP00000418456
ENST00000469787	ENSP00000417918
ENST00000471379
ENST00000461867	ENSP00000418888

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005355	glucose transmembrane transporter activity
GO:0015149	hexose transmembrane transporter activity
GO:0022857	transmembrane transporter activity
GO:0022891	substrate-specific transmembrane transporter activity
GO:0033300	dehydroascorbic acid transporter activity
GO:0055056	D-glucose transmembrane transporter activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006112	energy reserve metabolic process
GO:0008645	hexose transport
GO:0015758	glucose transport
GO:0031018	endocrine pancreas development
GO:0035428	hexose transmembrane transport
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0055085	transmembrane transport
GO:0070837	dehydroascorbic acid transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005903	brush border
GO:0016020	membrane
GO:0016021	integral component of membrane