InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS3

Summary

InnateDB Gene

IDBG-64727.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS3

Gene Name

ribosomal protein S3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000149273

Encoded Proteins

IDBP-64729

ribosomal protein S3

IDBP-381140

ribosomal protein S3

IDBP-585628

ribosomal protein S3

IDBP-599686

ribosomal protein S3

IDBP-584607

ribosomal protein S3

IDBP-592341

ribosomal protein S3

IDBP-597590

ribosomal protein S3

IDBP-591813

ribosomal protein S3

IDBP-587578

ribosomal protein S3

IDBP-599600

ribosomal protein S3

IDBP-590713

ribosomal protein S3

IDBP-598936

ribosomal protein S3

IDBP-590924

ribosomal protein S3

IDBP-592940

ribosomal protein S3

IDBP-586129

ribosomal protein S3

IDBP-597546

ribosomal protein S3

IDBP-595476

ribosomal protein S3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:75399486-75422280

Strand

Forward strand

Band

q13.4

Transcripts

ENST00000278572	ENSP00000278572
ENST00000422465	ENSP00000416745
ENST00000531188	ENSP00000434643
ENST00000529173
ENST00000528439	ENSP00000432542
ENST00000530164	ENSP00000433155
ENST00000530721	ENSP00000432458
ENST00000532872	ENSP00000431834
ENST00000534440	ENSP00000436335
ENST00000527446	ENSP00000436971
ENST00000526608	ENSP00000433421
ENST00000527273	ENSP00000435457
ENST00000524851	ENSP00000433821
ENST00000526248	ENSP00000431737
ENST00000529285
ENST00000534555
ENST00000528847	ENSP00000435566
ENST00000525933	ENSP00000436556
ENST00000525690	ENSP00000436476
ENST00000530170	ENSP00000437105

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 226 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	226 [view]
Protein-Protein	219 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0044822	poly(A) RNA binding
GO:0051018	protein kinase A binding
GO:0051059	NF-kappaB binding
GO:0051536	iron-sulfur cluster binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000737	DNA catabolic process, endonucleolytic
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0006974	cellular response to DNA damage stimulus
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process
GO:0045738	negative regulation of DNA repair
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:1902546	positive regulation of DNA N-glycosylase activity
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022627	cytosolic small ribosomal subunit
GO:0030529	ribonucleoprotein complex
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome
GO:0071159	NF-kappaB complex