InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPS3

Summary

InnateDB Protein

IDBP-587578.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS3

Protein Name

ribosomal protein S3

Synonyms

S3;

Species

Homo sapiens

Ensembl Protein

ENSP00000436971

InnateDB Gene

IDBG-64727 (RPS3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 226 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	226 [view]
Protein-Protein	219 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0044822	poly(A) RNA binding
GO:0051018	protein kinase A binding
GO:0051059	NF-kappaB binding
GO:0051536	iron-sulfur cluster binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000737	DNA catabolic process, endonucleolytic
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0006974	cellular response to DNA damage stimulus
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process
GO:0045738	negative regulation of DNA repair
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:1902546	positive regulation of DNA N-glycosylase activity
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022627	cytosolic small ribosomal subunit
GO:0030529	ribonucleoprotein complex
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome
GO:0071159	NF-kappaB complex

Protein Structure and Domains

PDB ID

InterPro

IPR001351 Ribosomal protein S3, C-terminal
IPR004044 K Homology domain, type 2
IPR005703 Ribosomal protein S3, eukaryotic/archaeal
IPR009019 K homology domain, prokaryotic type

PFAM

PF00189
PF07650

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P23396

PhosphoSite