Version 5.4
Bos taurus Gene: PURA
Summary
InnateDB Gene IDBG-647386.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PURA
Gene Name transcriptional activator protein Pur-alpha
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008881
Encoded Proteins
IDBP-700215
purine-rich element binding protein A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 22835829
[Homo sapiens] PURA expression is repressed by endogenous miRNA to restrict HIV-1 infection in monocytes.
PMID 22835829
[Mus musculus] Pura expression is repressed by endogenous miRNA to restrict HIV-1 infection in monocytes. (Demonstrated in human)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185129:
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:52983071-52984039
Strand Forward strand
Band
Transcripts
ENSBTAT00000011694 ENSBTAP00000040759
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000900 translation repressor activity, nucleic acid binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003691 double-stranded telomeric DNA binding
GO:0003697 single-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0032422 purine-rich negative regulatory element binding
GO:0044822 poly(A) RNA binding
GO:0046332 SMAD binding
Biological Process
GO:0006268 DNA unwinding involved in DNA replication
GO:0007399 nervous system development
GO:0008284 positive regulation of cell proliferation
GO:0017148 negative regulation of translation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005662 DNA replication factor A complex
GO:0005737 cytoplasm
GO:0030425 dendrite
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000185129
View Gene Order
ENSMUSG00000043991
View Gene Order
Cross-References
SwissProt
TrEMBL E1BMW9
UniProt Splice Variant
Entrez Gene 782746
UniGene Bt.91641
RefSeq NM_001205434 XM_005209486 XM_005209487
HUGO HGNC:9701
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02020426
GenPept
RNA Seq Atlas 782746

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca