InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PURA

Summary

InnateDB Gene

IDBG-48322.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PURA

Gene Name

purine-rich element binding protein A

Synonyms

PUR-ALPHA; PUR1; PURALPHA

Species

Homo sapiens

Ensembl Gene

ENSG00000185129

Encoded Proteins

IDBP-48324

purine-rich element binding protein A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22835829

PURA expression is repressed by endogenous miRNA to restrict HIV-1 infection in monocytes.

InnateDB Annotation from Orthologs

Summary

PMID 22835829

[Mus musculus] Pura expression is repressed by endogenous miRNA to restrict HIV-1 infection in monocytes. (Demonstrated in human)

Entrez Gene

Summary

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:140107777-140125619

Strand

Forward strand

Band

q31.3

Transcripts

ENST00000331327	ENSP00000332706
ENST00000505703
ENST00000502351

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	30 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000900	translation repressor activity, nucleic acid binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003691	double-stranded telomeric DNA binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0032422	purine-rich negative regulatory element binding
GO:0044822	poly(A) RNA binding
GO:0046332	SMAD binding

Biological Process

GO:0006268	DNA unwinding involved in DNA replication
GO:0006270	DNA replication initiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0017148	negative regulation of translation
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005662	DNA replication factor A complex
GO:0005737	cytoplasm
GO:0030425	dendrite
GO:0043025	neuronal cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000043991

View Gene Order

ENSBTAG00000008881

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.443121 Hs.617409 Hs.733468

RefSeq

NM_005859

HUGO

OMIM

CCDS

CCDS4220

HPRD

02721

IMGT

EMBL

GenPept

RNA Seq Atlas