InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.105583

Summary

InnateDB Gene

IDBG-647759.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.105583

Gene Name

frizzled-7 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002283

Encoded Proteins

IDBP-700557

frizzled-7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155760:
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
Members of the \'frizzled\' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:90987008-90989214

Strand

Forward strand

Band

Transcripts

ENSBTAT00000002946

ENSBTAP00000002946

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007166	cell surface receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0010812	negative regulation of cell-substrate adhesion
GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0016055	Wnt signaling pathway
GO:0019827	stem cell maintenance
GO:0033077	T cell differentiation in thymus
GO:0034446	substrate adhesion-dependent cell spreading
GO:0035412	regulation of catenin import into nucleus
GO:0035567	non-canonical Wnt signaling pathway
GO:0038031	non-canonical Wnt signaling pathway via JNK cascade
GO:0042327	positive regulation of phosphorylation
GO:0042666	negative regulation of ectodermal cell fate specification
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048103	somatic stem cell division
GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing
GO:0060070	canonical Wnt signaling pathway
GO:0060231	mesenchymal to epithelial transition