InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAN

Summary

InnateDB Gene

IDBG-64798.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAN

Gene Name

RAN, member RAS oncogene family

Synonyms

ARA24; Gsp1; TC4

Species

Homo sapiens

Ensembl Gene

ENSG00000132341

Encoded Proteins

IDBP-245794

RAN, member RAS oncogene family

IDBP-245796

RAN, member RAS oncogene family

IDBP-385105

RAN, member RAS oncogene family

IDBP-598095

RAN, member RAS oncogene family

IDBP-591479

RAN, member RAS oncogene family

IDBP-592308

RAN, member RAS oncogene family

IDBP-585038

RAN, member RAS oncogene family

IDBP-812847

RAN, member RAS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy\'s disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy\'s disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:130871879-130877678

Strand

Forward strand

Band

q24.33

Transcripts

ENST00000392369	ENSP00000376176
ENST00000392367	ENSP00000376174
ENST00000448750	ENSP00000396127
ENST00000477395
ENST00000464211
ENST00000543796	ENSP00000446215
ENST00000536606	ENSP00000437950
ENST00000537745
ENST00000541630	ENSP00000441210
ENST00000535090	ENSP00000444042
ENST00000541679	ENSP00000483687
ENST00000539498

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 150 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	150 [view]
Protein-Protein	148 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0019904	protein domain specific binding
GO:0044822	poly(A) RNA binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000055	ribosomal large subunit export from nucleus
GO:0000056	ribosomal small subunit export from nucleus
GO:0006184	GTP catabolic process
GO:0006259	DNA metabolic process
GO:0006611	protein export from nucleus
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007052	mitotic spindle organization
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007286	spermatid development
GO:0010467	gene expression
GO:0015031	protein transport
GO:0016032	viral process
GO:0019058	viral life cycle
GO:0030521	androgen receptor signaling pathway
GO:0032092	positive regulation of protein binding
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0075733	intracellular transport of virus

Cellular Component

GO:0000785	chromatin
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0042470	melanosome
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome