InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAN

Summary

InnateDB Protein

IDBP-245794.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAN

Protein Name

RAN, member RAS oncogene family

Synonyms

ARA24; Gsp1; TC4;

Species

Homo sapiens

Ensembl Protein

ENSP00000376176

InnateDB Gene

IDBG-64798 (RAN)

Protein Structure

UniProt Annotation

Function

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. {ECO:0000250}.Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.

Subcellular Localization

Nucleus. Cytoplasm. Melanosome. Note=Predominantly nuclear during interphase (By similarity). Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in a variety of tissues. {ECO:0000269PubMed:2108320}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 150 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	150 [view]
Protein-Protein	148 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000055	ribosomal large subunit export from nucleus
GO:0000056	ribosomal small subunit export from nucleus
GO:0006184	GTP catabolic process
GO:0006259	DNA metabolic process
GO:0006611	protein export from nucleus
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007052	mitotic spindle organization
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0010467	gene expression
GO:0015031	protein transport
GO:0016032	viral process
GO:0019058	viral life cycle
GO:0030521	androgen receptor signaling pathway
GO:0032092	positive regulation of protein binding
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0075733	intracellular transport of virus

Cellular Component

GO:0000785	chromatin
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF08477

PRINTS

PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt