InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLD1

Summary

InnateDB Gene

IDBG-64867.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLD1

Gene Name

phospholipase D1, phosphatidylcholine-specific

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000075651

Encoded Proteins

IDBP-64869

phospholipase D1, phosphatidylcholine-specific

IDBP-64873

phospholipase D1, phosphatidylcholine-specific

IDBP-385371

phospholipase D1, phosphatidylcholine-specific

IDBP-385374

phospholipase D1, phosphatidylcholine-specific

IDBP-385376

phospholipase D1, phosphatidylcholine-specific

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:171600405-171810950

Strand

Reverse strand

Band

q26.31

Transcripts

ENST00000356327	ENSP00000348681
ENST00000351298	ENSP00000342793
ENST00000446289	ENSP00000395556
ENST00000440204	ENSP00000391164
ENST00000418087	ENSP00000400639
ENST00000463281
ENST00000465816
ENST00000467432
ENST00000471075
ENST00000481505
ENST00000498278
ENST00000475273
ENST00000489995
ENST00000460926
ENST00000497307

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.

Experimentally validated
Total	35 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004630	phospholipase D activity
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding
GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006655	phosphatidylglycerol biosynthetic process
GO:0006935	chemotaxis
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0008152	metabolic process
GO:0016042	lipid catabolic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0000139	Golgi membrane
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0031902	late endosome membrane
GO:0048471	perinuclear region of cytoplasm