Version 5.4
Bos taurus Gene: GJA8
Summary
InnateDB Gene IDBG-648892.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GJA8
Gene Name Gap junction protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021833
Encoded Proteins
IDBP-701597
gap junction protein, alpha 8, 50kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121634:
This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:21859235-21860557
Strand Reverse strand
Band
Transcripts
ENSBTAT00000029102 ENSBTAP00000029102
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002088 lens development in camera-type eye
GO:0007154 cell communication
GO:0043010 camera-type eye development
Cellular Component
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0005922 connexon complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000121634
View Gene Order
ENSMUSG00000049908
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9509
Gap junction assembly pathway
REACT_9411
Gap junction trafficking pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MHI7
UniProt Splice Variant
Entrez Gene 524042
UniGene Bt.87266
RefSeq XM_005197758 XM_005204001
HUGO HGNC:4281
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02007326
GenPept
RNA Seq Atlas 524042

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca