Version 5.4
Mus musculus Gene: Gja8
Summary
InnateDB Gene IDBG-176662.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gja8
Gene Name gap junction protein, alpha 8
Synonyms Aey5; Cnx50; Cx50; Lop10
Species Mus musculus
Ensembl Gene ENSMUSG00000049908
Encoded Proteins
IDBP-176664
gap junction protein, alpha 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121634:
This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:96918863-96926020
Strand Reverse strand
Band F2.1
Transcripts
ENSMUST00000062944 ENSMUSP00000049532
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005243 gap junction channel activity
GO:0005515 protein binding
Biological Process
GO:0002088 lens development in camera-type eye
GO:0007154 cell communication
GO:0007267 cell-cell signaling
GO:0043010 camera-type eye development
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005922 connexon complex
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000121634
View Gene Order
ENSBTAG00000021833
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9509
Gap junction assembly pathway
REACT_9411
Gap junction trafficking pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P28236
TrEMBL Q548M7
UniProt Splice Variant
Entrez Gene 14616
UniGene Mm.468160
RefSeq NM_008123
OMIM
CCDS CCDS17651
HPRD
IMGT
MGI ID MGI:99953
MGI Symbol Gja8
EMBL AF304357 AF321120 BC120513 BC125569 CH466620 GU363513 GU363514 GU363515 M91243
GenPept AAA37497 AAG42241 AAG59880 AAI20514 AAI25570 ADC38984 ADC38985 ADC38986 EDL38928
RNA Seq Atlas 14616

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca