Version 5.4
Homo sapiens Gene: KLK15
Summary
InnateDB Gene IDBG-64923.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK15
Gene Name kallikrein-related peptidase 15
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174562
Encoded Proteins
IDBP-64925
kallikrein-related peptidase 15
IDBP-766091
IDBP-762950
IDBP-765371
IDBP-765989
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:50825289-50837213
Strand Reverse strand
Band q13.33
Transcripts
ENST00000326856 ENSP00000314783
ENST00000598673 ENSP00000472523
ENST00000596931 ENSP00000471164
ENST00000602114 ENSP00000468856
ENST00000598239 ENSP00000469315
ENST00000596531
ENST00000601680
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055193
View Gene Order
ENSBTAG00000018545
Not yet available
Cross-References
SwissProt
TrEMBL M0R2F7
UniProt Splice Variant
Entrez Gene 55554
UniGene Hs.567535
RefSeq NM_001277081 NM_001277082 NM_017509 XM_006723265
HUGO HGNC:20453
OMIM 610601
CCDS CCDS12805 CCDS12806 CCDS62766
HPRD 07490
IMGT
EMBL AC010325 AC011523
GenPept
RNA Seq Atlas 55554

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca