InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AXIN2

Summary

InnateDB Gene

IDBG-65085.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AXIN2

Gene Name

axin 2

Synonyms

AXIL; ODCRCS

Species

Homo sapiens

Ensembl Gene

ENSG00000168646

Encoded Proteins

IDBP-65087

axin 2

IDBP-65089

axin 2

IDBP-586825

axin 2

IDBP-759023

IDBP-758089

IDBP-758116

IDBP-809534

axin 2

IDBP-809535

axin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:65528563-65561647

Strand

Reverse strand

Band

q24.1

Transcripts

ENST00000307078	ENSP00000302625
ENST00000375702	ENSP00000364854
ENST00000544103	ENSP00000441151
ENST00000585045	ENSP00000463192
ENST00000577278	ENSP00000464264
ENST00000578251
ENST00000580513	ENSP00000463761
ENST00000611991	ENSP00000481191
ENST00000618960	ENSP00000478916

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	21 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0070016	armadillo repeat domain binding
GO:0070411	I-SMAD binding

Biological Process

GO:0001756	somitogenesis
GO:0001934	positive regulation of protein phosphorylation
GO:0001957	intramembranous ossification
GO:0003139	secondary heart field specification
GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009950	dorsal/ventral axis specification
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010942	positive regulation of cell death
GO:0030111	regulation of Wnt signaling pathway
GO:0030282	bone mineralization
GO:0032423	regulation of mismatch repair
GO:0034613	cellular protein localization
GO:0035414	negative regulation of catenin import into nucleus
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0042476	odontogenesis
GO:0043547	positive regulation of GTPase activity
GO:0043570	maintenance of DNA repeat elements
GO:0045668	negative regulation of osteoblast differentiation
GO:0048255	mRNA stabilization
GO:0061181	regulation of chondrocyte development
GO:0070602	regulation of centromeric sister chromatid cohesion
GO:0071407	cellular response to organic cyclic compound
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090244	Wnt signaling pathway involved in somitogenesis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005881	cytoplasmic microtubule
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0014069	postsynaptic density
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030877	beta-catenin destruction complex