InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Axin2

Summary

InnateDB Gene

IDBG-213782.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Axin2

Gene Name

axin2

Synonyms

Axi1; Axil; Conductin

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000142

Encoded Proteins

IDBP-213784

axin2

IDBP-268203

axin2

IDBP-532739

axin2

IDBP-536748

axin2

IDBP-531685

axin2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168646:
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:108920349-108950783

Strand

Forward strand

Band

Transcripts

ENSMUST00000052915	ENSMUSP00000051331
ENSMUST00000106711	ENSMUSP00000102322
ENSMUST00000140821	ENSMUSP00000120664
ENSMUST00000152909	ENSMUSP00000116956
ENSMUST00000144511	ENSMUSP00000119915
ENSMUST00000144130
ENSMUST00000139682

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0070016	armadillo repeat domain binding
GO:0070411	I-SMAD binding

Biological Process

GO:0001756	somitogenesis
GO:0001934	positive regulation of protein phosphorylation
GO:0001957	intramembranous ossification
GO:0003139	secondary heart field specification
GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0008219	cell death
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009950	dorsal/ventral axis specification
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010942	positive regulation of cell death
GO:0030111	regulation of Wnt signaling pathway
GO:0030282	bone mineralization
GO:0032423	regulation of mismatch repair
GO:0034613	cellular protein localization
GO:0035412	regulation of catenin import into nucleus
GO:0035414	negative regulation of catenin import into nucleus
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0042476	odontogenesis
GO:0043547	positive regulation of GTPase activity
GO:0043570	maintenance of DNA repeat elements
GO:0045668	negative regulation of osteoblast differentiation
GO:0048255	mRNA stabilization
GO:0061181	regulation of chondrocyte development
GO:0070602	regulation of centromeric sister chromatid cohesion
GO:0071407	cellular response to organic cyclic compound
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090244	Wnt signaling pathway involved in somitogenesis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005881	cytoplasmic microtubule
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0014069	postsynaptic density
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030877	beta-catenin destruction complex