InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAD51

Summary

InnateDB Gene

IDBG-6509.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD51

Gene Name

RAD51 homolog (S. cerevisiae)

Synonyms

BRCC5; HRAD51; HsRad51; HsT16930; MRMV2; RAD51A; RECA

Species

Homo sapiens

Ensembl Gene

ENSG00000051180

Encoded Proteins

IDBP-6511

RAD51 homolog (S. cerevisiae)

IDBP-6513

RAD51 homolog (S. cerevisiae)

IDBP-366349

RAD51 homolog (S. cerevisiae)

IDBP-600033

RAD51 homolog (S. cerevisiae)

IDBP-587439

RAD51 homolog (S. cerevisiae)

IDBP-587422

RAD51 homolog (S. cerevisiae)

IDBP-589594

RAD51 homolog (S. cerevisiae)

IDBP-600920

RAD51 homolog (S. cerevisiae)

IDBP-590978

RAD51 homolog (S. cerevisiae)

IDBP-601599

RAD51 homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:40694774-40732339

Strand

Forward strand

Band

q15.1

Transcripts

ENST00000382643	ENSP00000372088
ENST00000267868	ENSP00000267868
ENST00000423169	ENSP00000406602
ENST00000527860	ENSP00000432759
ENST00000557850	ENSP00000454176
ENST00000532743	ENSP00000433924
ENST00000525066	ENSP00000431864
ENST00000526763	ENSP00000431897
ENST00000531277	ENSP00000436512
ENST00000533741	ENSP00000433053

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 117 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	117 [view]
Protein-Protein	112 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008094	DNA-dependent ATPase activity
GO:0042802	identical protein binding
GO:0043142	single-stranded DNA-dependent ATPase activity
GO:0070182	DNA polymerase binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000730	DNA recombinase assembly
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006268	DNA unwinding involved in DNA replication
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0006312	mitotic recombination
GO:0006974	cellular response to DNA damage stimulus
GO:0007126	meiotic nuclear division
GO:0007131	reciprocal meiotic recombination
GO:0009432	SOS response
GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0051106	positive regulation of DNA ligation
GO:0051260	protein homooligomerization
GO:0071479	cellular response to ionizing radiation
GO:0072757	cellular response to camptothecin

Cellular Component

GO:0000228	nuclear chromosome
GO:0000793	condensed chromosome
GO:0000794	condensed nuclear chromosome
GO:0000800	lateral element
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005815	microtubule organizing center
GO:0016605	PML body
GO:0048471	perinuclear region of cytoplasm