InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rad51

Summary

InnateDB Gene

IDBG-198884.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rad51

Gene Name

RAD51 homolog (S. cerevisiae)

Synonyms

AV304093; Rad51a; Reca

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027323

Encoded Proteins

IDBP-198886

RAD51 homolog (S. cerevisiae)

IDBP-538087

RAD51 homolog (S. cerevisiae)

IDBP-533086

RAD51 homolog (S. cerevisiae)

IDBP-534968

RAD51 homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000051180:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:119112793-119147445

Strand

Forward strand

Band

Transcripts

ENSMUST00000028795	ENSMUSP00000028795
ENSMUST00000110828
ENSMUST00000140939	ENSMUSP00000119444
ENSMUST00000152327	ENSMUSP00000119101
ENSMUST00000141389
ENSMUST00000151406	ENSMUSP00000117939
ENSMUST00000154683
ENSMUST00000143934

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	10 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	68 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008094	DNA-dependent ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042802	identical protein binding
GO:0043142	single-stranded DNA-dependent ATPase activity
GO:0070182	DNA polymerase binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006268	DNA unwinding involved in DNA replication
GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007126	meiotic nuclear division
GO:0007131	reciprocal meiotic recombination
GO:0009432	SOS response
GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0051106	positive regulation of DNA ligation
GO:0051260	protein homooligomerization
GO:0071479	cellular response to ionizing radiation
GO:0072757	cellular response to camptothecin

Cellular Component

GO:0000228	nuclear chromosome
GO:0000793	condensed chromosome
GO:0000794	condensed nuclear chromosome
GO:0000795	synaptonemal complex
GO:0000800	lateral element
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005815	microtubule organizing center
GO:0016605	PML body
GO:0048471	perinuclear region of cytoplasm