Version 5.4
Homo sapiens Gene: APOH
Summary
InnateDB Gene IDBG-65172.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOH
Gene Name apolipoprotein H (beta-2-glycoprotein I)
Synonyms B2G1; B2GP1; BG
Species Homo sapiens
Ensembl Gene ENSG00000091583
Encoded Proteins
IDBP-65174
apolipoprotein H (beta-2-glycoprotein I)
IDBP-760253
IDBP-758025
IDBP-761804
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21965665
APOH is a plasma protein that specifically interacts with lipopolysaccharide (LPS) and TLR4 to induce TNF-alpha production in macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 21965665
[Mus musculus] Apoh is a plasma protein that specifically interacts with lipopolysaccharide (LPS) and Tlr4 to induce Tnf-alpha production in macrophages. (Demonstrated in human)
Entrez Gene
Summary Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:66212033-66256525
Strand Reverse strand
Band q24.2
Transcripts
ENST00000205948 ENSP00000205948
ENST00000577982 ENSP00000464301
ENST00000581797 ENSP00000463553
ENST00000585162 ENSP00000462260
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 19 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008201 heparin binding
GO:0008289 lipid binding
GO:0042802 identical protein binding
GO:0060230 lipoprotein lipase activator activity
Biological Process
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006641 triglyceride metabolic process
GO:0007597 blood coagulation, intrinsic pathway
GO:0010596 negative regulation of endothelial cell migration
GO:0016525 negative regulation of angiogenesis
GO:0030193 regulation of blood coagulation
GO:0030194 positive regulation of blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0031639 plasminogen activation
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0034197 triglyceride transport
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0051917 regulation of fibrinolysis
GO:0051918 negative regulation of fibrinolysis
Cellular Component
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0031012 extracellular matrix
GO:0034361 very-low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0042627 chylomicron
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000049
View Gene Order
ENSBTAG00000001915
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.445358
RefSeq NM_000042
HUGO
OMIM
CCDS CCDS11663
HPRD 00728
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca