InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOH

Summary

InnateDB Protein

IDBP-65174.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOH

Protein Name

apolipoprotein H (beta-2-glycoprotein I)

Synonyms

B2G1; B2GP1; BG;

Species

Homo sapiens

Ensembl Protein

ENSP00000205948

InnateDB Gene

IDBG-65172 (APOH)

Protein Structure

UniProt Annotation

Function

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed by the liver and secreted in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	19 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008201	heparin binding
GO:0008289	lipid binding
GO:0042802	identical protein binding
GO:0060230	lipoprotein lipase activator activity

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0006641	triglyceride metabolic process
GO:0007597	blood coagulation, intrinsic pathway
GO:0010596	negative regulation of endothelial cell migration
GO:0016525	negative regulation of angiogenesis
GO:0030193	regulation of blood coagulation
GO:0030194	positive regulation of blood coagulation
GO:0030195	negative regulation of blood coagulation
GO:0031639	plasminogen activation
GO:0033033	negative regulation of myeloid cell apoptotic process
GO:0034197	triglyceride transport
GO:0034392	negative regulation of smooth muscle cell apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0051917	regulation of fibrinolysis
GO:0051918	negative regulation of fibrinolysis

Cellular Component

GO:0005615	extracellular space
GO:0009986	cell surface
GO:0031012	extracellular matrix
GO:0034361	very-low-density lipoprotein particle
GO:0034364	high-density lipoprotein particle
GO:0042627	chylomicron
GO:0070062	extracellular vesicular exosome