Version 5.4
Homo sapiens Gene: CTBP1
Summary
InnateDB Gene IDBG-6522.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTBP1
Gene Name C-terminal binding protein 1
Synonyms BARS
Species Homo sapiens
Ensembl Gene ENSG00000159692
Encoded Proteins
IDBP-6524
C-terminal binding protein 1
IDBP-6526
C-terminal binding protein 1
IDBP-480788
C-terminal binding protein 1
IDBP-485262
C-terminal binding protein 1
IDBP-475606
C-terminal binding protein 1
IDBP-483018
C-terminal binding protein 1
IDBP-483109
C-terminal binding protein 1
IDBP-477765
C-terminal binding protein 1
IDBP-482603
C-terminal binding protein 1
IDBP-481273
C-terminal binding protein 1
IDBP-476839
C-terminal binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:1211448-1249953
Strand Reverse strand
Band p16.3
Transcripts
ENST00000290921 ENSP00000290921
ENST00000382952 ENSP00000372411
ENST00000382950
ENST00000503594 ENSP00000422148
ENST00000514596
ENST00000504092 ENSP00000422364
ENST00000510739 ENSP00000424575
ENST00000511907
ENST00000505826
ENST00000514669
ENST00000506180 ENSP00000424684
ENST00000504784 ENSP00000422730
ENST00000514210 ENSP00000426470
ENST00000514495
ENST00000515399 ENSP00000425053
ENST00000513420 ENSP00000420983
ENST00000510568 ENSP00000423872
ENST00000515690
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 157 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 157 [view]
Protein-Protein 154 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0019904 protein domain specific binding
GO:0042803 protein homodimerization activity
GO:0051287 NAD binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006098 pentose-phosphate shunt
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007030 Golgi organization
GO:0008152 metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0019079 viral genome replication
GO:0031065 positive regulation of histone deacetylation
GO:0034401 regulation of transcription by chromatin organization
GO:0035067 negative regulation of histone acetylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050872 white fat cell differentiation
GO:0051726 regulation of cell cycle
GO:0055114 oxidation-reduction process
GO:0090241 negative regulation of histone H4 acetylation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005829 cytosol
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037373
View Gene Order
ENSBTAG00000008480
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_8
Wnt pathway
REACTOME
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_111102
Signal Transduction pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228106
repression of WNT target genes pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04330
Notch signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
ps1pathway
Presenilin action in Notch and Wnt signaling
hes_heypathway
Notch-mediated HES/HEY network
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
atm_pathway
ATM pathway
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL E7EPF8 E7ESU7 E9PGB1 Q9NSY3
UniProt Splice Variant
Entrez Gene 1487
UniGene Hs.692303
RefSeq NM_001012614 NM_001328 XM_005272261 XM_005272262 XM_005272263
HUGO HGNC:2494
OMIM 602618
CCDS CCDS3348 CCDS43203
HPRD 04015
IMGT
EMBL AC092535 AL137653
GenPept CAB70861
RNA Seq Atlas 1487

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca