InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTBP1

Summary

InnateDB Protein

IDBP-6526.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTBP1

Protein Name

C-terminal binding protein 1

Synonyms

BARS;

Species

Homo sapiens

Ensembl Protein

ENSP00000372411

InnateDB Gene

IDBG-6522 (CTBP1)

Protein Structure

UniProt Annotation

Function

Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. {ECO:0000269PubMed:12419229, ECO:0000269PubMed:15542832, ECO:0000269PubMed:18212045, ECO:0000269PubMed:19103759, ECO:0000269PubMed:9858600}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12679040}. Nucleus {ECO:0000269PubMed:12679040}.

Disease Associations

Tissue Specificity

Expressed in germinal center B-cells. {ECO:0000269PubMed:18212045}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 157 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	157 [view]
Protein-Protein	154 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0019904	protein domain specific binding
GO:0051287	NAD binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006098	pentose-phosphate shunt
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0008152	metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0019079	viral genome replication
GO:0031065	positive regulation of histone deacetylation
GO:0034401	regulation of transcription by chromatin organization
GO:0035067	negative regulation of histone acetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050872	white fat cell differentiation
GO:0051726	regulation of cell cycle
GO:0055114	oxidation-reduction process
GO:0090241	negative regulation of histone H4 acetylation

Cellular Component

GO:0005634	nucleus
GO:0017053	transcriptional repressor complex

Protein Structure and Domains

PDB ID

InterPro

IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain

PFAM

PF03446
PF00389
PF02826

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13363

PhosphoSite