Version 5.4
Homo sapiens Gene: KLK10
Summary
InnateDB Gene IDBG-65446.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK10
Gene Name kallikrein-related peptidase 10
Synonyms NES1; PRSSL1
Species Homo sapiens
Ensembl Gene ENSG00000129451
Encoded Proteins
IDBP-65448
kallikrein-related peptidase 10
IDBP-65450
kallikrein-related peptidase 10
IDBP-246952
kallikrein-related peptidase 10
IDBP-760460
IDBP-763053
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:51012739-51020175
Strand Reverse strand
Band q13.41
Transcripts
ENST00000358789 ENSP00000351640
ENST00000309958 ENSP00000311746
ENST00000391805 ENSP00000375681
ENST00000599077 ENSP00000471610
ENST00000599987
ENST00000601467 ENSP00000472773
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007049 cell cycle
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030693
View Gene Order
ENSBTAG00000015129
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.275464 Hs.703454
RefSeq NM_001077500 NM_002776 NM_145888 XM_005259061 XM_005259062 XM_006723287 XM_006723288 XM_006723289
HUGO
OMIM
CCDS CCDS12817
HPRD 04054
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca