Version 5.4
Homo sapiens Protein: KLK10
Summary
InnateDB Protein IDBP-65450.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK10
Protein Name kallikrein-related peptidase 10
Synonyms NES1; PRSSL1;
Species Homo sapiens
Ensembl Protein ENSP00000311746
InnateDB Gene IDBG-65446 (KLK10)
Protein Structure
UniProt Annotation
Function Has a tumor-suppressor role for NES1 in breast and prostate cancer.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in breast, ovary and prostate.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007049 cell cycle
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43240
PhosphoSite PhosphoSite-
TrEMBL M0R132
UniProt Splice Variant
Entrez Gene 5655
UniGene Hs.703454
RefSeq NP_002767
HUGO HGNC:6358
OMIM 602673
CCDS CCDS12817
HPRD 04054
IMGT
EMBL AC011473 AF024605 AF055481 AF243527 AY561635 BC002710
GenPept AAB81602 AAC14266 AAG23256 AAG33363 AAH02710 AAS66976

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca