Version 5.4
Homo sapiens Gene: KLK14
Summary
InnateDB Gene IDBG-65632.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK14
Gene Name kallikrein-related peptidase 14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000129437
Encoded Proteins
IDBP-65634
kallikrein-related peptidase 14
IDBP-246958
kallikrein-related peptidase 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. An additional transcript variant has been described but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:51077495-51084245
Strand Reverse strand
Band q13.41
Transcripts
ENST00000156499 ENSP00000156499
ENST00000391802 ENSP00000375678
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0009566 fertilization
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
GO:0048730 epidermis morphogenesis
GO:0070684 seminal clot liquefaction
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044737
View Gene Order
ENSBTAG00000012538
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.283925
RefSeq NM_022046 XM_006723225
HUGO
OMIM
CCDS CCDS12823
HPRD 05844
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca