InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLK14

Summary

InnateDB Protein

IDBP-246958.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLK14

Protein Name

kallikrein-related peptidase 14

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000375678

InnateDB Gene

IDBG-65632 (KLK14)

Protein Structure

UniProt Annotation

Function

Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. {ECO:0000269PubMed:15654974, ECO:0000269PubMed:16885167, ECO:0000269PubMed:17158887, ECO:0000269PubMed:17625593, ECO:0000269PubMed:18056261, ECO:0000269PubMed:18482984}.

Subcellular Localization

Secreted, extracellular space {ECO:0000269PubMed:15654974, ECO:0000269PubMed:16456535, ECO:0000269PubMed:17110383}.

Disease Associations

Tissue Specificity

Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid, kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40 tissues tested, the highest expression is detected in skin followed by breast and prostate (at protein level). Expressed in stratum corneum by sweat ducts and sweat glands and detected in sweat (at protein level). {ECO:0000269PubMed:10969073, ECO:0000269PubMed:11309303, ECO:0000269PubMed:11352573, ECO:0000269PubMed:16456535, ECO:0000269PubMed:16800737, ECO:0000269PubMed:17110383}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0009566	fertilization
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
GO:0048730	epidermis morphogenesis
GO:0070684	seminal clot liquefaction