Version 5.4
Homo sapiens Gene: RSF1
Summary
InnateDB Gene IDBG-65690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RSF1
Gene Name remodeling and spacing factor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000048649
Encoded Proteins
IDBP-65692
remodeling and spacing factor 1
IDBP-381490
remodeling and spacing factor 1
IDBP-595533
remodeling and spacing factor 1
IDBP-592952
remodeling and spacing factor 1
IDBP-592567
remodeling and spacing factor 1
IDBP-593355
remodeling and spacing factor 1
IDBP-586724
remodeling and spacing factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:77659996-77821017
Strand Reverse strand
Band q14.1
Transcripts
ENST00000308488 ENSP00000311513
ENST00000440064 ENSP00000408844
ENST00000480887 ENSP00000434509
ENST00000467567
ENST00000529470
ENST00000531026 ENSP00000433603
ENST00000526324 ENSP00000432022
ENST00000531768
ENST00000532556 ENSP00000436728
ENST00000528095 ENSP00000436408
ENST00000534794
ENST00000530604
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042393 histone binding
Biological Process
GO:0006334 nucleosome assembly
GO:0006338 chromatin remodeling
GO:0006352 DNA-templated transcription, initiation
GO:0006355 regulation of transcription, DNA-templated
GO:0016584 nucleosome positioning
GO:0034080 centromere-specific nucleosome assembly
GO:0043392 negative regulation of DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050434 positive regulation of viral transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0031213 RSF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035623
View Gene Order
ENSBTAG00000020268
Not yet available
Pathways
NETPATH
REACTOME
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_115566
Cell Cycle pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.420229 Hs.572073 Hs.593415 Hs.614113 Hs.711667 Hs.743733
RefSeq NM_016578 XM_005274051
HUGO
OMIM
CCDS CCDS8253
HPRD 10537
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca