InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RSF1

Summary

InnateDB Protein

IDBP-65692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RSF1

Protein Name

remodeling and spacing factor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000311513

InnateDB Gene

IDBG-65690 (RSF1)

Protein Structure

UniProt Annotation

Function

Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF- alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain. {ECO:0000269PubMed:11788598, ECO:0000269PubMed:12972596}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11788598, ECO:0000269PubMed:11944984}.

Disease Associations

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042393	histone binding

Biological Process

GO:0006334	nucleosome assembly
GO:0006338	chromatin remodeling
GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0016584	nucleosome positioning
GO:0034080	centromere-specific nucleosome assembly
GO:0043392	negative regulation of DNA binding
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050434	positive regulation of viral transcription