Version 5.4
Homo sapiens Gene: ARSG
Summary
InnateDB Gene IDBG-65797.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARSG
Gene Name arylsulfatase G
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000141337
Encoded Proteins
IDBP-383702
arylsulfatase G
IDBP-383703
arylsulfatase G
IDBP-764847
IDBP-812695
arylsulfatase G
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:68259182-68422731
Strand Forward strand
Band q24.2
Transcripts
ENST00000452479 ENSP00000413953
ENST00000448504 ENSP00000407193
ENST00000582154
ENST00000581032
ENST00000590690
ENST00000578554
ENST00000581639 ENSP00000462306
ENST00000578726
ENST00000621439 ENSP00000480910
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004065 arylsulfatase activity
GO:0008484 sulfuric ester hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006790 sulfur compound metabolic process
GO:0008152 metabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020604
View Gene Order
ENSBTAG00000010637
Not yet available
Pathways
NETPATH
REACTOME
REACT_121036
The activation of arylsulfatases pathway
REACT_116105
Glycosphingolipid metabolism pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_1069
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_17015
Metabolism of proteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL J3KS49
UniProt Splice Variant
Entrez Gene 22901
UniGene Hs.437249 Hs.605017
RefSeq NM_001267727 NM_014960 XM_005257172 XM_006721776 XM_006721777 XM_006721778 XM_006721779 XM_006721780
HUGO HGNC:24102
OMIM 610008
CCDS CCDS11676
HPRD 13826
IMGT
EMBL AC005332 AC007780
GenPept
RNA Seq Atlas 22901

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca