Version 5.4
Homo sapiens Gene: KCNMB3
Summary
InnateDB Gene IDBG-66050.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNMB3
Gene Name potassium large conductance calcium-activated channel, subfamily M beta member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171121
Encoded Proteins
IDBP-66052
potassium large conductance calcium-activated channel, subfamily M beta member 3
IDBP-66054
potassium large conductance calcium-activated channel, subfamily M beta member 3
IDBP-245155
potassium large conductance calcium-activated channel, subfamily M beta member 3
IDBP-245157
potassium large conductance calcium-activated channel, subfamily M beta member 3
IDBP-806619
potassium large conductance calcium-activated channel, subfamily M beta member 3
IDBP-484243
potassium large conductance calcium-activated channel, subfamily M beta member 3
IDBP-485136
potassium large conductance calcium-activated channel, subfamily M beta member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:179236691-179267002
Strand Reverse strand
Band q26.32
Transcripts
ENST00000314235 ENSP00000319370
ENST00000349697 ENSP00000327866
ENST00000392686 ENSP00000376452
ENST00000392685 ENSP00000376451
ENST00000486944 ENSP00000479162
ENST00000497599 ENSP00000417091
ENST00000485523 ENSP00000418536
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015269 calcium-activated potassium channel activity
GO:0015459 potassium channel regulator activity
Biological Process
GO:0001508 action potential
GO:0005513 detection of calcium ion
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0019228 neuronal action potential
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000091091
View Gene Order
ENSBTAG00000009235
Not yet available
Pathways
NETPATH
REACTOME
REACT_23767
cGMP effects pathway
REACT_23862
Nitric oxide stimulates guanylate cyclase pathway
REACT_23876
Platelet homeostasis pathway
REACT_75896
Ca2+ activated K+ channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
REACT_604
Hemostasis pathway
KEGG
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591285
RefSeq NM_001163677 NM_014407 NM_171828 NM_171829 NM_171830
HUGO
OMIM
CCDS CCDS3225 CCDS3226 CCDS43172 CCDS43173 CCDS54683
HPRD 05563
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca