Version 5.4
Homo sapiens Protein: KCNMB3
Summary
InnateDB Protein IDBP-66054.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNMB3
Protein Name potassium large conductance calcium-activated channel, subfamily M beta member 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000327866
InnateDB Gene IDBG-66050 (KCNMB3)
Protein Structure
UniProt Annotation
Function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. {ECO:0000269PubMed:10766764, ECO:0000269PubMed:10864947}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis. {ECO:0000269PubMed:10585773, ECO:0000269PubMed:10692449, ECO:0000269PubMed:10766764}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015269 calcium-activated potassium channel activity
GO:0015459 potassium channel regulator activity
Biological Process
GO:0001508 action potential
GO:0005513 detection of calcium ion
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0019228 neuronal action potential
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR003930 Potassium channel, calcium-activated, BK, beta subunit
PFAM PF03185
PRINTS PR01450
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NPA1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 27094
UniGene Hs.591285
RefSeq NP_741979
HUGO HGNC:6287
OMIM 605222
CCDS CCDS3225
HPRD 05563
IMGT
EMBL AC007823 AC076966 AF139471 AF160968 AF170916 AF204159 AF204160 AF204161 AF204162 AF214561 AK304837 CH471052
GenPept AAD54771 AAF36598 AAF67811 AAF89698 AAF97031 AAF97032 AAF97033 AAF97034 BAH14265 EAW78418 EAW78421

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca