InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HAS1

Summary

InnateDB Gene

IDBG-66243.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HAS1

Gene Name

hyaluronan synthase 1

Synonyms

HAS

Species

Homo sapiens

Ensembl Gene

ENSG00000105509

Encoded Proteins

IDBP-66245

hyaluronan synthase 1

IDBP-597146

hyaluronan synthase 1

IDBP-760381

IDBP-761132

IDBP-765927

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. [provided by RefSeq, Jul 2008]
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:51713112-51723994

Strand

Reverse strand

Band

q13.41

Transcripts

ENST00000222115	ENSP00000222115
ENST00000540069	ENSP00000445021
ENST00000601667	ENSP00000471953
ENST00000601714	ENSP00000472821
ENST00000594621	ENSP00000469165

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0050501	hyaluronan synthase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0007155	cell adhesion
GO:0010764	negative regulation of fibroblast migration
GO:0030203	glycosaminoglycan metabolic process
GO:0030212	hyaluronan metabolic process
GO:0030213	hyaluronan biosynthetic process
GO:0036120	cellular response to platelet-derived growth factor stimulus
GO:0044281	small molecule metabolic process
GO:0045226	extracellular polysaccharide biosynthetic process
GO:0085029	extracellular matrix assembly