Version 5.4
Homo sapiens Gene: SLC17A4
Summary
InnateDB Gene IDBG-66333.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC17A4
Gene Name solute carrier family 17 (sodium phosphate), member 4
Synonyms KAIA2138
Species Homo sapiens
Ensembl Gene ENSG00000146039
Encoded Proteins
IDBP-66335
solute carrier family 17 (sodium phosphate), member 4
IDBP-236157
solute carrier family 17 (sodium phosphate), member 4
IDBP-365134
solute carrier family 17 (sodium phosphate), member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:25754699-25781191
Strand Forward strand
Band p22.2
Transcripts
ENST00000377905 ENSP00000367137
ENST00000397076 ENSP00000380266
ENST00000439485 ENSP00000391345
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005436 sodium:phosphate symporter activity
Biological Process
GO:0006796 phosphate-containing compound metabolic process
GO:0006814 sodium ion transport
GO:0035435 phosphate ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021336
View Gene Order
ENSBTAG00000037738
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.282931 Hs.606644
RefSeq NM_001286121 NM_005495
HUGO
OMIM
CCDS CCDS4564 CCDS75411
HPRD 05022
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca