InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC17A4

Summary

InnateDB Protein

IDBP-66335.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC17A4

Protein Name

solute carrier family 17 (sodium phosphate), member 4

Synonyms

KAIA2138;

Species

Homo sapiens

Ensembl Protein

ENSP00000367137

InnateDB Gene

IDBG-66333 (SLC17A4)

Protein Structure

UniProt Annotation

Function

Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro). {ECO:0000269PubMed:22460716}.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:22460716}; Multi-pass membrane protein {ECO:0000269PubMed:22460716}. Cell membrane {ECO:0000269PubMed:22460716}; Multi-pass membrane protein {ECO:0000269PubMed:22460716}. Note=Apical in the intestinal brush border.

Disease Associations

Tissue Specificity

Abundantly expressed in pancreas, liver, colon and small intestine, less in kidney. Not detected in the adrenal glands, brain, placenta, heart, testis, skeletal muscle, and lungs. {ECO:0000269PubMed:10319585, ECO:0000269PubMed:22460716}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005436	sodium:phosphate symporter activity

Biological Process

GO:0006796	phosphate-containing compound metabolic process
GO:0006814	sodium ion transport
GO:0035435	phosphate ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y2C5

PhosphoSite