Version 5.4
Homo sapiens Gene: DLG2
Summary
InnateDB Gene IDBG-66339.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLG2
Gene Name discs, large homolog 2 (Drosophila)
Synonyms chapsyn-110; PPP1R58; PSD-93; PSD93
Species Homo sapiens
Ensembl Gene ENSG00000150672
Encoded Proteins
IDBP-66341
discs, large homolog 2 (Drosophila)
IDBP-66345
discs, large homolog 2 (Drosophila)
IDBP-233365
discs, large homolog 2 (Drosophila)
IDBP-233364
discs, large homolog 2 (Drosophila)
IDBP-233367
discs, large homolog 2 (Drosophila)
IDBP-233369
discs, large homolog 2 (Drosophila)
IDBP-233371
discs, large homolog 2 (Drosophila)
IDBP-294244
discs, large homolog 2 (Drosophila)
IDBP-381685
discs, large homolog 2 (Drosophila)
IDBP-381688
discs, large homolog 2 (Drosophila)
IDBP-381700
discs, large homolog 2 (Drosophila)
IDBP-381703
discs, large homolog 2 (Drosophila)
IDBP-381708
discs, large homolog 2 (Drosophila)
IDBP-598904
discs, large homolog 2 (Drosophila)
IDBP-589219
discs, large homolog 2 (Drosophila)
IDBP-602010
discs, large homolog 2 (Drosophila)
IDBP-588466
discs, large homolog 2 (Drosophila)
IDBP-603793
discs, large homolog 2 (Drosophila)
IDBP-597139
discs, large homolog 2 (Drosophila)
IDBP-596003
discs, large homolog 2 (Drosophila)
IDBP-587579
discs, large homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:83455012-85627922
Strand Reverse strand
Band q14.1
Transcripts
ENST00000280241 ENSP00000280241
ENST00000376104 ENSP00000365272
ENST00000330014 ENSP00000381353
ENST00000398309 ENSP00000381355
ENST00000398304 ENSP00000381349
ENST00000398301 ENSP00000381346
ENST00000398299 ENSP00000381344
ENST00000404783 ENSP00000385113
ENST00000418306 ENSP00000402275
ENST00000426717 ENSP00000393049
ENST00000457267 ENSP00000409133
ENST00000420775 ENSP00000391017
ENST00000434967 ENSP00000403239
ENST00000456295
ENST00000472545
ENST00000529159
ENST00000524982 ENSP00000432894
ENST00000532653 ENSP00000435849
ENST00000531015 ENSP00000433848
ENST00000524601 ENSP00000436020
ENST00000530800 ENSP00000436302
ENST00000529399 ENSP00000434346
ENST00000529111
ENST00000524941
ENST00000529401 ENSP00000434095
ENST00000527466
ENST00000527088 ENSP00000435809
ENST00000530589
ENST00000530260
ENST00000526147
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 28 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004385 guanylate kinase activity
GO:0005515 protein binding
Biological Process
GO:0007268 synaptic transmission
GO:0010923 negative regulation of phosphatase activity
GO:0019233 sensory perception of pain
GO:0046939 nucleotide phosphorylation
Cellular Component
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0044224 juxtaparanode region of axon
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000052572
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.367656
RefSeq NM_001142699 NM_001142700 NM_001142702 NM_001206769 NM_001300983 NM_001364 XM_005273805 XM_005273806 XM_005273807 XM_005273809 XM_005273810 XM_005273811 XM_006718438 XM_006718439
HUGO
OMIM
CCDS CCDS41696 CCDS44690 CCDS44691 CCDS44692 CCDS55782 CCDS73357
HPRD 08220
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca