InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC20A1

Summary

InnateDB Gene

IDBG-66416.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC20A1

Gene Name

solute carrier family 20 (phosphate transporter), member 1

Synonyms

Glvr-1; GLVR1; PiT-1; PIT1

Species

Homo sapiens

Ensembl Gene

ENSG00000144136

Encoded Proteins

IDBP-66418

solute carrier family 20 (phosphate transporter), member 1

IDBP-384801

solute carrier family 20 (phosphate transporter), member 1

IDBP-384802

solute carrier family 20 (phosphate transporter), member 1

IDBP-384804

solute carrier family 20 (phosphate transporter), member 1

IDBP-384805

solute carrier family 20 (phosphate transporter), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:112645857-112663827

Strand

Forward strand

Band

q14.1

Transcripts

ENST00000272542	ENSP00000272542
ENST00000423633	ENSP00000392050
ENST00000433924	ENSP00000390021
ENST00000456264	ENSP00000403763
ENST00000413135	ENSP00000413393
ENST00000498224
ENST00000480984
ENST00000492076
ENST00000490674

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004872	receptor activity
GO:0005315	inorganic phosphate transmembrane transporter activity
GO:0005316	high affinity inorganic phosphate:sodium symporter activity
GO:0005436	sodium:phosphate symporter activity

Biological Process

GO:0006796	phosphate-containing compound metabolic process
GO:0006810	transport
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006817	phosphate ion transport
GO:0007165	signal transduction
GO:0035435	phosphate ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027397

View Gene Order

ENSBTAG00000007895

Not yet available

Pathways

NETPATH

REACTOME

REACT_19275

Sodium-coupled phosphate cotransporters pathway

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

H7C3Q9

UniProt Splice Variant

Entrez Gene

6574

UniGene

Hs.187946 Hs.729866

RefSeq

NM_005415 XM_005263743

HUGO

HGNC:10946

OMIM

137570

CCDS

CCDS2099

HPRD

08846

IMGT

EMBL

AC079922

GenPept

RNA Seq Atlas

6574