InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC20A1

Summary

InnateDB Protein

IDBP-66418.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC20A1

Protein Name

solute carrier family 20 (phosphate transporter), member 1

Synonyms

Glvr-1; GLVR1; PiT-1; PIT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000272542

InnateDB Gene

IDBG-66416 (SLC20A1)

Protein Structure

UniProt Annotation

Function

Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269PubMed:11009570, ECO:0000269PubMed:12097582, ECO:0000269PubMed:1309898, ECO:0000269PubMed:1531369, ECO:0000269PubMed:2078500, ECO:0000269PubMed:7929240, ECO:0000269PubMed:7966619, ECO:0000269PubMed:8041748}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:2078500}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004872	receptor activity
GO:0005315	inorganic phosphate transmembrane transporter activity
GO:0005316	high affinity inorganic phosphate:sodium symporter activity
GO:0005436	sodium:phosphate symporter activity

Biological Process

GO:0006796	phosphate-containing compound metabolic process
GO:0006810	transport
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006817	phosphate ion transport
GO:0007165	signal transduction
GO:0035435	phosphate ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0055085	transmembrane transport