Version 5.4
Homo sapiens Gene: SLC17A3
Summary
InnateDB Gene IDBG-66488.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC17A3
Gene Name solute carrier family 17 (sodium phosphate), member 3
Synonyms NPT4
Species Homo sapiens
Ensembl Gene ENSG00000124564
Encoded Proteins
IDBP-66490
solute carrier family 17 (sodium phosphate), member 3
IDBP-66492
solute carrier family 17 (sodium phosphate), member 3
IDBP-236195
solute carrier family 17 (sodium phosphate), member 3
IDBP-365317
solute carrier family 17 (sodium phosphate), member 3
IDBP-473418
solute carrier family 17 (sodium phosphate), member 3
IDBP-478928
solute carrier family 17 (sodium phosphate), member 3
IDBP-474147
solute carrier family 17 (sodium phosphate), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:25833066-25882286
Strand Reverse strand
Band p22.2
Transcripts
ENST00000360657 ENSP00000353873
ENST00000361703 ENSP00000355307
ENST00000308453
ENST00000397060 ENSP00000380250
ENST00000449356 ENSP00000415622
ENST00000481949 ENSP00000421855
ENST00000505420 ENSP00000424027
ENST00000509714
ENST00000506105 ENSP00000424729
ENST00000503922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005436 sodium:phosphate symporter activity
GO:0008308 voltage-gated anion channel activity
GO:0008514 organic anion transmembrane transporter activity
GO:0015143 urate transmembrane transporter activity
GO:0015238 drug transmembrane transporter activity
GO:0015562 efflux transmembrane transporter activity
GO:0019534 toxin transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0006817 phosphate ion transport
GO:0006855 drug transmembrane transport
GO:0015711 organic anion transport
GO:0015747 urate transport
GO:0015760 glucose-6-phosphate transport
GO:0015849 organic acid transport
GO:0015893 drug transport
GO:0034220 ion transmembrane transport
GO:0035435 phosphate ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0046415 urate metabolic process
GO:0055085 transmembrane transport
GO:1901998 toxin transport
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036083
View Gene Order
ENSBTAG00000003797
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O00476
TrEMBL H0Y9F7
UniProt Splice Variant
Entrez Gene 10786
UniGene Hs.327179
RefSeq NM_001098486 NM_006632
HUGO HGNC:10931
OMIM 611034
CCDS CCDS47385 CCDS4566
HPRD 10233
IMGT
EMBL AK298271 AL138726 BC017952 CH471087 U90545
GenPept AAB53423 AAH17952 BAH12747 CAC16543 EAW55495
RNA Seq Atlas 10786

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca