InnateDB Protein
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IDBP-236195.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC17A3
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Protein Name
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solute carrier family 17 (sodium phosphate), member 3
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Synonyms
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NPT4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380250
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InnateDB Gene
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IDBG-66488 (SLC17A3)
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Protein Structure
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Function |
Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.
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Subcellular Localization |
Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein.Isoform 2: Cell membrane {ECO:0000269PubMed:20810651}; Multi-pass membrane protein {ECO:0000269PubMed:20810651}.
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Disease Associations |
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Tissue Specificity |
Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level). {ECO:0000269PubMed:20810651, ECO:0000269PubMed:9149941}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0005436
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sodium:phosphate symporter activity
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GO:0008308
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voltage-gated anion channel activity
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GO:0008514
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organic anion transmembrane transporter activity
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GO:0015143
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urate transmembrane transporter activity
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GO:0015238
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drug transmembrane transporter activity
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GO:0015562
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efflux transmembrane transporter activity
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GO:0019534
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toxin transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011701
Major facilitator superfamily
IPR016196
Major facilitator superfamily domain, general substrate transporter
IPR020846
Major facilitator superfamily domain
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PFAM |
PF07690
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O00476
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PhosphoSite |
PhosphoSite-O00476
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TrEMBL |
H0Y9F7
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UniProt Splice Variant |
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Entrez Gene |
10786
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UniGene |
Hs.327179
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RefSeq |
NP_001091956
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HUGO |
HGNC:10931
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OMIM |
611034
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CCDS |
CCDS47385
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HPRD |
10233
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IMGT |
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EMBL |
AK298271
AL138726
BC017952
CH471087
U90545
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GenPept |
AAB53423
AAH17952
BAH12747
CAC16543
EAW55495
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