Version 5.4
Homo sapiens Gene: MTPAP
Summary
InnateDB Gene IDBG-66585.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTPAP
Gene Name mitochondrial poly(A) polymerase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000107951
Encoded Proteins
IDBP-66587
mitochondrial poly(A) polymerase
IDBP-371622
mitochondrial poly(A) polymerase
IDBP-371625
mitochondrial poly(A) polymerase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:30309801-30374448
Strand Reverse strand
Band p11.23
Transcripts
ENST00000263063 ENSP00000263063
ENST00000417581 ENSP00000404392
ENST00000421701 ENSP00000394118
ENST00000488290
ENST00000471055
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0002134 UTP binding
GO:0004652 polynucleotide adenylyltransferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006378 mRNA polyadenylation
GO:0008219 cell death
GO:0071044 histone mRNA catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024234
View Gene Order
ENSBTAG00000004387
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.173946
RefSeq NM_018109
HUGO
OMIM
CCDS CCDS7165
HPRD 15097
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca