InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FZD4

Summary

InnateDB Gene

IDBG-67034.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZD4

Gene Name

frizzled family receptor 4

Synonyms

CD344; EVR1; FEVR; Fz-4; Fz4; FZD4S; FzE4; GPCR; hFz4

Species

Homo sapiens

Ensembl Gene

ENSG00000174804

Encoded Proteins

IDBP-589917

frizzled family receptor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:86945679-86955391

Strand

Reverse strand

Band

q14.2

Transcripts

ENST00000531380

ENSP00000434034

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0019955	cytokine binding
GO:0030165	PDZ domain binding
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity
GO:0042813	Wnt-activated receptor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001553	luteinization
GO:0001568	blood vessel development
GO:0001570	vasculogenesis
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway
GO:0007420	brain development
GO:0007605	sensory perception of sound
GO:0010812	negative regulation of cell-substrate adhesion
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031987	locomotion involved in locomotory behavior
GO:0034446	substrate adhesion-dependent cell spreading
GO:0035426	extracellular matrix-cell signaling
GO:0042701	progesterone secretion
GO:0043507	positive regulation of JUN kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060070	canonical Wnt signaling pathway
GO:0061299	retina vasculature morphogenesis in camera-type eye
GO:0061301	cerebellum vasculature morphogenesis
GO:0061304	retinal blood vessel morphogenesis
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome