Version 5.4
Bos taurus Gene: FZD4
Summary
InnateDB Gene IDBG-641882.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FZD4
Gene Name frizzled-4 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000040128
Encoded Proteins
IDBP-694288
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174804:
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:8669606-8673380
Strand Forward strand
Band
Transcripts
ENSBTAT00000061370 ENSBTAP00000053606
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0019955 cytokine binding
GO:0030165 PDZ domain binding
GO:0031625 ubiquitin protein ligase binding
GO:0042803 protein homodimerization activity
GO:0042813 Wnt-activated receptor activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001553 luteinization
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0007166 cell surface receptor signaling pathway
GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway
GO:0007275 multicellular organismal development
GO:0007605 sensory perception of sound
GO:0010812 negative regulation of cell-substrate adhesion
GO:0016055 Wnt signaling pathway
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031987 locomotion involved in locomotory behavior
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035426 extracellular matrix-cell signaling
GO:0042701 progesterone secretion
GO:0043507 positive regulation of JUN kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060070 canonical Wnt signaling pathway
GO:0061299 retina vasculature morphogenesis in camera-type eye
GO:0061301 cerebellum vasculature morphogenesis
GO:0061304 retinal blood vessel morphogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000174804
View Gene Order
ENSMUSG00000049791
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_8
Wnt pathway
REACTOME
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_172581
PCP/CE pathway pathway
REACT_172761
Ca2+ pathway pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_172599
WNT5A-dependent internalization of FZD4 pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_200716
regulation of FZD by ubiquitination pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_172638
Asymmetric localization of PCP proteins pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_21340
GPCR ligand binding pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
REACT_222404
WNT5A-dependent internalization of FZD4 pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_254215
Signaling by GPCR pathway
REACT_250061
Class B/2 (Secretin family receptors) pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_213035
regulation of FZD by ubiquitination pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_214043
PCP/CE pathway pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_231468
GPCR ligand binding pathway
REACT_221970
Ca2+ pathway pathway
REACT_188257
Signal Transduction pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa05217
Basal cell carcinoma pathway
hsa04916
Melanogenesis pathway
hsa05200
Pathways in cancer pathway
mmu05217
Basal cell carcinoma pathway
mmu04916
Melanogenesis pathway
mmu04310
Wnt signaling pathway pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
Wnt signaling pathway pathway
INOH website
GPCR signaling pathway
INOH website
Wnt signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
wnt_signaling_pathway
Wnt signaling network
Cross-References
SwissProt
TrEMBL F1MLJ8 Q1MW19
UniProt Splice Variant
Entrez Gene 445416
UniGene Bt.76547
RefSeq NM_001206269
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB257753 DAAA02062527
GenPept BAE93504
RNA Seq Atlas 445416
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca