InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD300A

Summary

InnateDB Gene

IDBG-67271.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD300A

Gene Name

CD300a molecule

Synonyms

CLM-8; CMRF-35-H9; CMRF-35H; CMRF35-H; CMRF35-H9; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC1/IRC2; IRC2; IRp60

Species

Homo sapiens

Ensembl Gene

ENSG00000167851

Encoded Proteins

IDBP-67273

CD300a molecule

IDBP-67275

CD300a molecule

IDBP-67277

CD300a molecule

IDBP-245278

CD300a molecule

IDBP-762228

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22043923

CD300A inhibits MYD88 and/or TRIF-mediated TLR signalling pathway through activation of PTPN6.

Entrez Gene

Summary

This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:74466416-74484796

Strand

Forward strand

Band

q25.1

Transcripts

ENST00000360141	ENSP00000353259
ENST00000310828	ENSP00000308188
ENST00000361933	ENSP00000354564
ENST00000392625	ENSP00000376401
ENST00000582319
ENST00000577511	ENSP00000463189

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0005515	protein binding
GO:0008429	phosphatidylethanolamine binding
GO:0038023	signaling receptor activity

Biological Process

GO:0002376	immune system process
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0030889	negative regulation of B cell proliferation
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0033007	negative regulation of mast cell activation involved in immune response
GO:0043305	negative regulation of mast cell degranulation
GO:0043407	negative regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0048147	negative regulation of fibroblast proliferation
GO:0050856	regulation of T cell receptor signaling pathway
GO:0050859	negative regulation of B cell receptor signaling pathway
GO:0051134	negative regulation of NK T cell activation
GO:0060101	negative regulation of phagocytosis, engulfment
GO:1902564	negative regulation of neutrophil activation
GO:1902567	negative regulation of eosinophil activation
GO:1902569	negative regulation of activation of JAK2 kinase activity
GO:2000417	negative regulation of eosinophil migration

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

No orthologs found for this gene

Cross-References

SwissProt

Q9UGN4

TrEMBL

J3QKQ4

UniProt Splice Variant

Entrez Gene

11314

UniGene

Hs.742559 Hs.9688

RefSeq

NM_001256841 NM_007261 XM_005256990

HUGO

HGNC:19319

OMIM

606790

CCDS

CCDS32720 CCDS58590

HPRD

IMGT

EMBL

AC079325 AF020314 AF161346 AF176985 AF176986 AF176987 AF176988 AF176989 AF176990 AF176991 AJ010101 AJ010102 AJ010103 AJ224864 AJ238323 BC032352

GenPept

AAD01646 AAF28906 AAF89957 AAH32352 CAB52291 CAB52292 CAB52293 CAB55347 CAB66145

RNA Seq Atlas

11314