InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD300A

Summary

InnateDB Protein

IDBP-67277.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD300A

Protein Name

CD300a molecule

Synonyms

CLM-8; CMRF-35-H9; CMRF-35H; CMRF35-H; CMRF35-H9; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC1/IRC2; IRC2; IRp60;

Species

Homo sapiens

Ensembl Protein

ENSP00000354564

InnateDB Gene

IDBG-67271 (CD300A)

Protein Structure

UniProt Annotation

Function

Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. {ECO:0000269PubMed:10746781, ECO:0000269PubMed:16339535, ECO:0000269PubMed:9701027}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. {ECO:0000269PubMed:10540326, ECO:0000269PubMed:16339535, ECO:0000269PubMed:9701027}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0005515	protein binding
GO:0008429	phosphatidylethanolamine binding
GO:0038023	signaling receptor activity

Biological Process

GO:0002376	immune system process
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0030889	negative regulation of B cell proliferation
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0033007	negative regulation of mast cell activation involved in immune response
GO:0043305	negative regulation of mast cell degranulation
GO:0043407	negative regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0048147	negative regulation of fibroblast proliferation
GO:0050856	regulation of T cell receptor signaling pathway
GO:0050859	negative regulation of B cell receptor signaling pathway
GO:0051134	negative regulation of NK T cell activation
GO:0060101	negative regulation of phagocytosis, engulfment
GO:1902564	negative regulation of neutrophil activation
GO:1902567	negative regulation of eosinophil activation
GO:1902569	negative regulation of activation of JAK2 kinase activity
GO:2000417	negative regulation of eosinophil migration