InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRIN2C

Summary

InnateDB Gene

IDBG-67631.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIN2C

Gene Name

glutamate receptor, ionotropic, N-methyl D-aspartate 2C

Synonyms

GluN2C; NMDAR2C; NR2C

Species

Homo sapiens

Ensembl Gene

ENSG00000161509

Encoded Proteins

IDBP-67633

glutamate receptor, ionotropic, N-methyl D-aspartate 2C

IDBP-67635

glutamate receptor, ionotropic, N-methyl D-aspartate 2C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson\'s disease, Alzheimer\'s disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:74842023-74861504

Strand

Reverse strand

Band

q25.1

Transcripts

ENST00000347612	ENSP00000338645
ENST00000293190	ENSP00000293190
ENST00000578159
ENST00000584176
ENST00000584496

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005261	cation channel activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006810	transport
GO:0006812	cation transport
GO:0007215	glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0008104	protein localization
GO:0009611	response to wounding
GO:0033058	directional locomotion
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042177	negative regulation of protein catabolic process
GO:0042391	regulation of membrane potential
GO:0050885	neuromuscular process controlling balance
GO:0060079	regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0030425	dendrite
GO:0045211	postsynaptic membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020734

View Gene Order

ENSBTAG00000040042

Not yet available

Pathways

NETPATH

REACTOME

REACT_20546

Ras activation uopn Ca2+ infux through NMDA receptor pathway

REACT_20568

CREB phosphorylation through the activation of Ras pathway

REACT_20642

CREB phosphorylation through the activation of CaMKII pathway

REACT_20594

Unblocking of NMDA receptor, glutamate binding and activation pathway

REACT_13685

Neuronal System pathway

REACT_20593

Post NMDA receptor activation events pathway

REACT_20563

Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04720

Long-term potentiation pathway

hsa05010

Alzheimer's disease pathway

hsa04020

Calcium signaling pathway pathway

hsa05014

Amyotrophic lateral sclerosis (ALS) pathway

INOH

INOH website

GPCR Dopamine D1like receptor signaling pathway pathway

PID NCI

Cross-References

SwissProt

TrEMBL

H0Y2V8 Q8IW23

UniProt Splice Variant

Entrez Gene

2905

UniGene

Hs.436980

RefSeq

NM_001278553 NM_000835 XM_006721845 XM_006721846 XM_006721847

HUGO

HGNC:4587

OMIM

138254

CCDS

CCDS62330 CCDS32724

HPRD

00699

IMGT

EMBL

AC068874 BC041128 CH471099

GenPept

AAH41128 EAW89202

RNA Seq Atlas

2905