InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grin2c

Summary

InnateDB Gene

IDBG-214257.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grin2c

Gene Name

glutamate receptor, ionotropic, NMDA2C (epsilon 3)

Synonyms

GluN2C; NMDAR2C; NR2C

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020734

Encoded Proteins

IDBP-214261

glutamate receptor, ionotropic, NMDA2C (epsilon 3)

IDBP-268532

glutamate receptor, ionotropic, NMDA2C (epsilon 3)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161509:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson\'s disease, Alzheimer\'s disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:115249169-115267243

Strand

Reverse strand

Band

Transcripts

ENSMUST00000003351	ENSMUSP00000003351
ENSMUST00000106554	ENSMUSP00000102164

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005261	cation channel activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006810	transport
GO:0006812	cation transport
GO:0008104	protein localization
GO:0009611	response to wounding
GO:0033058	directional locomotion
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042177	negative regulation of protein catabolic process
GO:0042391	regulation of membrane potential
GO:0050885	neuromuscular process controlling balance
GO:0060079	regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005737	cytoplasm
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0030425	dendrite
GO:0045211	postsynaptic membrane