Version 5.4
Homo sapiens Gene: HIST1H1T
Summary
InnateDB Gene IDBG-67833.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST1H1T
Gene Name histone cluster 1, H1t
Synonyms dJ221C16.2; H1FT; H1t
Species Homo sapiens
Ensembl Gene ENSG00000187475
Encoded Proteins
IDBP-67835
histone cluster 1, H1t
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:26107419-26108136
Strand Reverse strand
Band p22.2
Transcripts
ENST00000338379 ENSP00000341214
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006334 nucleosome assembly
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007339 binding of sperm to zona pellucida
GO:0030154 cell differentiation
GO:0030317 sperm motility
Cellular Component
GO:0000786 nucleosome
GO:0000794 condensed nuclear chromosome
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P22492
TrEMBL
UniProt Splice Variant
Entrez Gene 3010
UniGene Hs.533293
RefSeq NM_005323
HUGO HGNC:4720
OMIM 142712
CCDS CCDS34349
HPRD
IMGT
EMBL AF531301 BC069517 M60094 M97755
GenPept AAA19936 AAA35944 AAH69517 AAN06701
RNA Seq Atlas 3010

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca