Version 5.4
Homo sapiens Gene: ASIP
Summary
InnateDB Gene IDBG-68022.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASIP
Gene Name agouti signaling protein
Synonyms AGSW; AGTI; AGTIL; ASP; SHEP9
Species Homo sapiens
Ensembl Gene ENSG00000101440
Encoded Proteins
IDBP-68024
agouti signaling protein
IDBP-710300
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:34194569-34269344
Strand Forward strand
Band q11.22
Transcripts
ENST00000374954 ENSP00000364092
ENST00000568305 ENSP00000454804
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0031779 melanocortin receptor binding
GO:0031781 type 3 melanocortin receptor binding
GO:0031782 type 4 melanocortin receptor binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008343 adult feeding behavior
GO:0009755 hormone-mediated signaling pathway
GO:0032402 melanosome transport
GO:0032438 melanosome organization
GO:0040030 regulation of molecular function, epigenetic
GO:0042438 melanin biosynthetic process
GO:0043473 pigmentation
GO:0071514 genetic imprinting
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027596
View Gene Order
ENSBTAG00000034077
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04916
Melanogenesis pathway
INOH
PID NCI
insulin_glucose_pathway
Insulin-mediated glucose transport
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.659995
RefSeq NM_001672 XM_005260412
HUGO
OMIM
CCDS CCDS13232
HPRD 02562
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca