Version 5.4
Homo sapiens Protein: ASIP
Summary
InnateDB Protein IDBP-68024.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASIP
Protein Name agouti signaling protein
Synonyms AGSW; AGTI; AGTIL; ASP; SHEP9;
Species Homo sapiens
Ensembl Protein ENSP00000364092
InnateDB Gene IDBG-68022 (ASIP)
Protein Structure
UniProt Annotation
Function Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and foreskin.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
Biological Process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0009755 hormone-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR007733 Agouti
IPR027300 Agouti domain
PFAM PF05039
PRINTS
PIRSF
SMART SM00792
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P42127
PhosphoSite PhosphoSite-P42127
TrEMBL
UniProt Splice Variant
Entrez Gene 434
UniGene Hs.659995
RefSeq NP_001663
HUGO HGNC:745
OMIM 600201
CCDS CCDS13232
HPRD 02562
IMGT
EMBL AL035458 BC104238 BC104239 L37019 U12770 U12774 U12775
GenPept AAA89208 AAB61247 AAI04239 AAI04240 CAB96679

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca