Version 5.4
Homo sapiens Gene: LILRB3
Summary
InnateDB Gene IDBG-68373.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LILRB3
Gene Name leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204577
Encoded Proteins
IDBP-68319
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
IDBP-68321
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
IDBP-247063
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
IDBP-384719
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
IDBP-384729
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54216278-54223506
Strand Reverse strand
Band q13.42
Transcripts
ENST00000245620 ENSP00000245620
ENST00000346401 ENSP00000345184
ENST00000391750 ENSP00000375630
ENST00000414379 ENSP00000416920
ENST00000445347 ENSP00000388199
ENST00000436504
ENST00000460208
ENST00000469273
ENST00000468668
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0006952 defense response
GO:0007166 cell surface receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045671 negative regulation of osteoclast differentiation
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04662
B cell receptor signaling pathway pathway
hsa04380
Osteoclast differentiation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 11025
UniGene Hs.631592
RefSeq NM_001081450 NM_006864
HUGO HGNC:6607
OMIM 604820
CCDS CCDS33105 CCDS46175
HPRD 11995
IMGT
EMBL
GenPept
RNA Seq Atlas 102724997 102725015 102725027 102725029 102725031 102725034 102725035 102725273 11025

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca