InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LILRB3

Summary

InnateDB Protein

IDBP-68319.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LILRB3

Protein Name

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000245620

InnateDB Gene

IDBG-68373 (LILRB3)

Protein Structure

UniProt Annotation

Function

May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B- cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM) (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Detected in monocytes and B-cells. {ECO:0000269PubMed:9548455}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding

Biological Process

GO:0002376	immune system process
GO:0006952	defense response
GO:0007166	cell surface receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045671	negative regulation of osteoclast differentiation