Version 5.4
Homo sapiens Gene: LILRB2
Summary
InnateDB Gene IDBG-68447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LILRB2
Gene Name leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
Synonyms CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10; MIR10
Species Homo sapiens
Ensembl Gene ENSG00000131042
Encoded Proteins
IDBP-68449
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
IDBP-247065
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
IDBP-247067
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
IDBP-247071
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
IDBP-384821
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
IDBP-384822
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
IDBP-808865
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54238904-54281184
Strand Reverse strand
Band q13.42
Transcripts
ENST00000314446 ENSP00000319960
ENST00000391749 ENSP00000375629
ENST00000391748 ENSP00000375628
ENST00000391746 ENSP00000375626
ENST00000455108 ENSP00000394130
ENST00000434421 ENSP00000410117
ENST00000493242
ENST00000471216
ENST00000612280 ENSP00000484266
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0008157 protein phosphatase 1 binding
GO:0023029 MHC class Ib protein binding
GO:0032396 inhibitory MHC class I receptor activity
GO:0042288 MHC class I protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0002578 negative regulation of antigen processing and presentation
GO:0002666 positive regulation of T cell tolerance induction
GO:0002767 immune response-inhibiting cell surface receptor signaling pathway
GO:0002774 Fc receptor mediated inhibitory signaling pathway
GO:0006955 immune response
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0032755 positive regulation of interleukin-6 production
GO:0034113 heterotypic cell-cell adhesion
GO:0042102 positive regulation of T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0050776 regulation of immune response
GO:0051926 negative regulation of calcium ion transport
GO:0071222 cellular response to lipopolysaccharide
GO:2001198 regulation of dendritic cell differentiation
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04380
Osteoclast differentiation pathway
INOH
PID NCI
Cross-References
SwissProt Q8N423
TrEMBL A2IXV5
UniProt Splice Variant
Entrez Gene 10288
UniGene Hs.655652
RefSeq NM_001080978 NM_001278403 NM_001278404 NM_001278405 NM_001278406 NM_005874 XM_006722967 XM_006722970
HUGO HGNC:6606
OMIM 604815
CCDS CCDS42612 CCDS12886 CCDS62791 CCDS62792
HPRD 11994
IMGT
EMBL AC010518 AF004231 AF025528 AF283986 AF283987 BC036827
GenPept AAB67711 AAB87662 AAH36827 AAL36990 AAL36991
RNA Seq Atlas 10288

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca